EPIFLO^®, a portable, 3 ounce device, is designed to heal chronic skin wounds – wounds that have failed to heal for 60 days or more-- by providing continuous oxygen flow to the wound site 24/7. The therapy boosts metabolism and re-establishes tissue function. The formation of new collagen, granulation, angiogenesis and epithelialization are all oxygen dependent and oxygen driven. Some clinicians suggest that EPIFLO^® mimics the bloodstream in delivering oxygen to ischemic cells surrounding the chronic wound thus providing metabolic energy to allow normal wound healing to progress.

Case report studies are available on this web site and additional clinical data will be posted as available.

Clinical poster presentations

• Transdermal Continuous Oxygen Therapy for Chronic Wound Management
  — Presented at the Canadian Association of Wound Care, London ON November 2007
  
  
• Continuous Local Oxygen Delivery Promotes Wound Healing
  — Presented at the Symposium on Advanced Wound Care, Las Vegas, NV, 2003
  
  
• Amputation Date Cancelled Due to the Use of Transdermal, Sustained Oxygen Therapy in the Healing of a Diabetic Foot Ulcer with Osteomyelitis
  — Presented at the American Professional Wound Care Association, Philadelphia, PA, 2005

Publications

• Hirsch, Fred; Berlin, Steven; Holtz, Aliza. "Transdermal Oxygen Delivery to Diabetic Wounds: A Study of 6 Cases." Submitted for Publication August, 2008.
  
  
• Said HK, Hijjawi J, Roy N, Mogford J, Mustoe T., “Transdermal sustained-delivery oxygen improves epithelial healing in a rabbit ear wound model.” Arch Surg. 2005 Oct;140(10):998-1004.
  
  
• Wilson, C. et al. J. Wound, Ostomy & Continence Nursing, 2005, 32(3S): Supplement 2: S6



• Scott GF, Reeves RE., “Topical Oxygen Alters Angiogenesis Related Growth Factor Expression in Chronic Diabetic Foot Ulcers.” Presented at: New Cardiovascular Horizons; Oct 1, 2005; Fort Worth, Texas.


• Davis, S. Cazzaniga, A., Ricotti, C., Zalesky, P. et al. “Topical Oxygen Emulsion: A Novel Wound Therapy.” Arch. Dermatol. 2007;143(10):1252-1256.